Roeselare that are languishing at the bottom of the first division inflicted a stunning defeat on the reigning champions beating them 1 - 0.
The Roeselare goal came from Dequevy shortly after half-time.
Club Brugge 1 KV Mechelen 1
Club Brugge that is second in the league drew 1 - 1 against KV Mechelen.
Destorme first took Mechelen into the lead, while Kouemaha later equalised for Club.
Following 18 games Club Brugge are now 7 points adrift of Anderlecht that beat Westerlo on Friday night.
Germinal 0 Charleroi 0
Germinal failed to impress against Charleroi. Charleroi spent most of the first half on the Germinal half of the pitch, but failed to pose any danger.
Germinal got off to a better start after half-time, but neither team was able to create many interesting chances. The match ended in a goalless draw.
Sint-Truiden 0 Kortrijk 2
All season goalie Simon Mignolet has been one of the key players at Sint-Truiden, but on Saturday night he got off to a porr start. He made a bad job of deflecting a ball in the third minute and Benkö was able top score for Kortrijk.
Sint-Truiden went in search of an equaliser, but Kortrijk goalie Verbauwhede made this impossible. A long goal from Benteke took the score to 2 - 0. Kortrijk are now fifth in the league.
Mouscron 0 Lokeren 5
Janczyck took Lokeren into an early lead against Mouscron. Later in the match he repeated the feat with a header and towards half-time he made it a hat trick.
Mouscron were powerless. Carevic even made it 4 - 0 and a header from Doll put 5 - 0 on the scoreboard.