Vandebroeck was first to take the home eleven into the lead just before half time.
The Buffaloes' revenge came late in the day with Custovic equalising towards the end of the match.
Lepoint secured victory for the Ghent eleven two minutes later just before the final whistle was able to sound.
Zulte no match for Anderlecht
Later in the evening Anderlecht trounced Zulte Waregem 6 - 0 at home. Zulte Waregem were clearly no match for the Brussels side that heads the first division.
Boussoufa was first to score in the opening stages of the match. The five other goals came in the second half. Suarez, Van Damme, De Sutter and Gillet all scored.
Boussoufa made the visitor's humiliation complete by making his second goal of the match in the 84th minute.
Anderlecht now lead the Play-off I group with 38 points. Club Brugge are second, AA Gent third with Kortrijk in fourth position. Zulte Waregem in sixth place hold the wooden spoon.