Despite having lost the first leg of the tie 2-1, Standard had high hopes of making it to the semi-finals.
Just one goal would be enough, if they could prevent the Germans from scoring.
However, it was not to be and Hamburg claimed their second Belgian scalp of their Europa League campaign.
The Germans took the initiative and went one up on 19 minutes through Mladen Petric.
Suddenly Standard's task seemed a whole lot harder.
However, the Champions were given fresh hope when Captain Igor De Camargo equalised on 31 minutes with a header that appeared to be off-side.
Standard’s joy was short lived as Petric scored his second goal of the night just three minutes later.
The Germans remained In the driving seat throughout the rest of the match and Jose Paolo Guerrero put the final nail in Standard’s coffin a minute from time to make the score 3-1 to Hamburg on the night and 5-2 on aggregate.
This brought to an end an impressive European campaign go further that it had done for 28 years.