Clijsters, who is from Limburg province, returned to competitive tennis in 2009 after a two-year retirement.
She is currently 10th in the WTA rankings.
The Fleming reached the final of the French Open in 2001 and 2003.
However, the 26-year-old has not entered the clay court tournament since 2006 when she reached the semi-finals.
Canada’s Stephanie Dubois will take Kim Clijsters' place at Roland Garros.