The Belgian Champions Sporting Anderlecht will take on the Serbian side Partisan Belgrade for a place in this season’s Champions League.
Anderlecht must first travel to the Serbian capital on either 17 or 18 August, before playing the second leg of the tie on home turf on either 24 or 25 August.
In the play-offs for a place in the Europa League, last season’s league runners-up AA Gent will face a tough challenge when they take on the Dutch side Feyenoord.
Like the other Europa League play-off ties, the two-leg Low Countries derby will be played on 19 and 25 August.
The first leg will be played in Rotterdam.
Racing Genk also face tough opponents in the shape of the Portuguese team FC Porto.
The first leg will be played in Genk.
As the only seeded team amongst the Belgian clubs in the draw, Club Brugge got off relatively lightly.
The West Flemings have been drawn against Belarusian side Dynamo Minsk.
Club will play the first leg of their tie at home.