The West Flemings beat Dinamo Minsk of Belarus 2 - 1 at home.
Dragon was first to score for Minsk. The two Club goals came from Hoefkens and Blondel.
Earlier in the evening AA Gent lost their away match against Feyenoord of the Netherlands 1 - 0. Fer scored in the 79th minute.
Racing Genk experienced an awful night. They were thrashed 3 - 0 at home by Porto of Portugal.
Falcao, Souza and Balluschi all scored.
The second legs are played next week.