Antwerp’s goals came from Owusu on 22 minutes and Biset on 71 minutes.
Of the other First Division clubs in action only Sporting Anderlecht had any trouble seeing off their lower league opponents.
Although Anderlecht eventually won their match against Fourth Division Spouwen-Mopertingen 3-1, it wasn’t until the 89th minute that Leander Dedoncker put them 2-1 up with Suarez making it 3-1 in the second minute of injury time.
The games other goals came on 65 minutes (a Tielemans penalty for Anderlecht) and 75 minutes with Moussa Diallo’s goal for Spouwen-Mopertingen.
The evening’s other results
Westerlo 3-2 Cercle Brugge (II)
Racing Genk 5-2 Dessel Sport (II)
KV Mechelen 1-0 WS Brussel (II)
Waasland-Beveren 2-1 Dender (III)
Kortrijk 5-0 Olsa Brakel (III)
Lokeren 6-2 Deux-Acren (III)
Sporting Charleroi 3-0 Walhain (III)
AA Gent 3-0 Eupen (II)
Patro Eisden Maasmechelen (II) 0-4 Club Brugge
STVV 1-0 Bocholt (III)
Koksijde (II) 2-3 Standard de Liège
OH Leuven 3-2 Lommel United (II)
Deinze (II) 0-2 Mouscron-Péruwelz
The draw for the next round
• AA Gent - Zulte Waregem
• Racing Genk - Charleroi
• KV Kortrijk - Anderlecht
• Westerlo - Antwerp (II)
• Mouscron-Péruwelz - OH Leuven
• Standard - STVV
• Club Brugge - Lokeren
• KV Mechelen - Waasland-Beveren
The matches will be played on 2 December