The news comes as the company marks its 25-year-presence at Brussels Airport. Delta's first direct flight between Brussels and New York flew on 1 November 1991. Since that year Delta has carried 4.8 million passengers between Belgium and the US.
The Brussels-Atlanta run was cancelled following the March attacks. The link between Atlanta, the world's largest airport and Delta's main hub, and Brussels will be a daily service during the summer high season.
Delta operates a daily flight between Brussels and New York with connections onto Las Vegas, Orlando, Los Angeles and San Francisco.